Author

Rui Gonçalo Martinho

University of LisbonORCID 0000-0002-1641-3403Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Pedro PrudêncioiD· 2 shared Adrian DraziciD· 1 shared Alexander J. WhitworthiD· 1 shared Alexandra FaustinoiD· 1 shared Amy H.Y. TongiD· 1 shared Annelies BogaertiD· 1 shared Barbara Kellen· 1 shared Brenda AndrewsiD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Pedro PrudêncioORCID

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3 papers

Recent·Most cited

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy H.Y. Tong, Simonetta Andreazza, , Thomas Arnesen

The paper shows that N-terminal acetylation by NatC protects proteins from degradation, enhancing longevity and motility, and that UBR4-KCMF1 targets unacetylated N-terminal Met followed by hydrophobic residues.

Nature Communications · Oct 27, 2023Peer-reviewedMolecular Biology

Transcription and splicing dynamics during early Drosophila development

Pedro Prudêncio, Rosina Savisaar, Kenny Rebelo, Rui Gonçalo Martinho, Maria Carmo‐Fonseca

This study uses NET-seq to analyze co-transcriptional splicing dynamics in Drosophila embryos, revealing differences in splicing timing and intron definition across developmental stages.

RNA · Oct 19, 2021Peer-reviewedMolecular Biology

The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization

Pedro Prudêncio, Leonardo Gastón Guilgur, João Sobral, Jörg Dieter Becker, Rui Gonçalo Martinho, Paulo Navarro‐Costa

This study shows that dMLL3/4 is essential for the transition to embryo fate at fertilization by promoting gene expression needed for zygotic genome assembly.

EMBO Reports · Jul 23, 2018Peer-reviewedDevelopmental Biology