Michael Gotthardt

This study investigates cardiac myofibril remodeling in Burmese pythons during digestion using multi-omics approaches, revealing post-translational modifications as key to increased contractility.

The paper investigates E-rich domain variants of RBM20, showing they reduce protein abundance and cause splicing defects, but are not rescued by RBM20 overexpression.

This study maps alternative splicing dynamics during human cardiac development and identifies splicing markers in iPSC-derived cardiomyocytes, revealing both similarities and differences with native cardiac splicing patterns.

This study shows that butyrate improves diastolic function and reduces fibrosis in hypertensive HFpEF rats by serving as an alternative energy source.

This study uses mCherry-titin mice to visualize sarcomere dynamics during skeletal muscle development and injury repair, revealing titin mobility and localization patterns in myocytes.

This study uses base editors and AAVMYO to correct Rbm20 mutations in cardiomyocytes, improving splicing and cardiac function in mouse models of dilated cardiomyopathy.

This study shows SURF1 mutations impair human neurogenesis by generating patient-derived iPS cells and demonstrating defects in neuronal differentiation and bioenergetics.