Elspeth A. Bruford

High-quality peptide evidence for annotating non-canonical open reading frames as human proteins

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

RNAcentral in 2026: Genes and literature integration

RNAcentral integrates literature and gene-level data to enhance non-coding RNA sequence analysis and functional understanding.

An expanded reference catalog of translated open reading frames for biomedical research

The paper expands and refines a reference catalog of human non-canonical open reading frames (ncORFs) by incorporating more datasets and introducing a translation signature score framework to prioritize high-quality ncORFs.

The VGNC: Expanding Standardized Vertebrate Gene Nomenclature

The paper describes the VGNC project, which standardizes gene nomenclature across vertebrate species, and reports its current status and availability.

A community-driven roadmap to advance research on translated open reading frames detected by Ribo-seq

This paper outlines a community-driven initiative to create a consolidated catalog of human Ribo-seq ORFs, addressing the lack of standardized annotation for these features.

The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources

The paper describes the formation of the Gene Curation Coalition to standardize gene-disease validity terminology and create a unified database for curated gene-disease assertions.

LY6S, a New Interferon-Inducible Human Member of the Ly6a-Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

The paper identifies LY6S, a new human interferon-inducible gene associated with inflammation and viral resistance, and describes its expression and functional effects.