Ariel Bazzini

This study identifies DCP5 as a key regulator of circadian RNA stability in Arabidopsis by modulating the decay of high-amplitude clock-controlled genes.

The paper identifies Cth1 as a spatio-temporally regulated maternal RNA decay factor essential for zebrafish development, showing its role in promoting deadenylation and decay of maternal mRNAs.

This study shows that Cth1 is essential for gametogenesis and fertility in zebrafish, with loss of function causing infertility and gamete abnormalities.

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

The paper uses CRISPR-RfxCas13d screening in zebrafish to identify Bckdk as a post-translational regulator of the maternal-to-zygotic transition, showing its role in ZGA and miR-430 processing.

The paper expands and refines a reference catalog of human non-canonical open reading frames (ncORFs) by incorporating more datasets and introducing a translation signature score framework to prioritize high-quality ncORFs.

This study optimizes CRISPR-Cas13d for RNA targeting in zebrafish by improving gRNA design, nuclear targeting, and computational prediction, reducing collateral effects.

The paper identifies five maternal mRNAs critical for zebrafish embryogenesis and reveals Cth1's role as a spatio-temporal RNA decay factor.

This study shows that dengue virus uses non-optimal codons in both human and mosquito cells, enhancing its fitness and suggesting synonymous codon choice is critical in host-pathogen interactions.

The paper identifies two micropeptides encoded by lincRNAs that regulate chromatin accessibility in vertebrate-specific neural cells and show their role in brain development.

iCodon predicts mRNA stability through codon composition and generates optimized or deoptimized mRNA variants for four vertebrate species.

This paper outlines a community-driven initiative to create a consolidated catalog of human Ribo-seq ORFs, addressing the lack of standardized annotation for these features.

This study demonstrates that CRISPR-Cas13d efficiently knocks down specific mRNAs in zebrafish, medaka, killifish, and mouse embryos, leading to significant transcript level reduction and embryonic phenotypes.