Avital Sarusi-Portuguez

This study identifies CD45 as a tuft cell-intrinsic checkpoint that limits intestinal type 2 immunity through an IL-13-induced negative feedback mechanism.

This study shows intestinal stem cells use TLR2 to sense microbes, coordinating epithelial defense and regeneration.

This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.

The paper identifies a ubiquitin network that maintains enterocyte identity by degrading stem-cell related translational machinery, which is disrupted with aging.

The paper identifies LY6S, a new human interferon-inducible gene associated with inflammation and viral resistance, and describes its expression and functional effects.

This study identifies TENT4A as a regulator of DNA-damage tolerance through multiple pathways, with mutations in these pathways linked to endometrial cancer.

This study identifies how the glucocorticoid receptor (GR) activates or represses genes by sequestering Ep300 and interacting with other transcription factors in 3D chromatin structures.