ImmunologybioRxiv
Major role of S-glycoprotein in providing immunogenicity and protective immunity in mRNA lipid nanoparticle vaccines based on SARS-CoV-2 structural proteins
Evgeniia N. Bykonia, Denis A. Kleymenov, Vladimir A. Gushchin…·Alexander L. Gintsburg
This study evaluates mRNA-LNP vaccines encoding SARS-CoV-2 structural proteins, finding that the S protein enhances immune responses to N protein, while M protein has low immunogenicity.
DOI 10.3390/vaccines12040379