Genetic and preclinical evidence implicating chondroitin sulfate as a matritherapeutic target for the treatment of type 2 diabetes
Valdemar Brimnes Ingemann Johansen, Jens Teglgaard Lund, María J Romero-Lado, Alberte Wollesen Breum, Charlotte Svendsen, Kasper Suhr Jørgensen, Rebecca Louise Miller, Andreas Mæchel Fritzen, Tuomas O. Kilpeläinen, Katrine T.-B. G. Schjoldager, Christoffer Clemmensen
This study identifies chondroitin sulfate as a potential therapeutic target for type 2 diabetes through genetic and preclinical evidence showing its effects on glycemic control and insulin action.
bioRxiv · Nov 12, 2025 · PreprintPhysiology