Katrine T.-B. G. Schjoldager

Inward and Outward Tethers Read Out the Spontaneous Curvature of Cellular Membranes

This paper introduces a method to measure spontaneous curvature in cellular membranes using tether pulling and simulations, revealing baseline negative curvature and its modulation by treatments.

Mimics of the chordate gut-brain hormone neurotensin in parasitic intestinal hookworms

This study identifies a new family of hookworm peptides that mimic the chordate gut-brain hormone neurotensin, showing structural and functional similarity to modulate gut function.

Molecular Regulation and Physiological Role of 1 GOLPH3-mediated Golgi retention

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

The Ligand Preference of LRP1 is Regulated by O-glycans

The paper shows that O-glycans in LRP1's ligand-binding domains differentially modulate uptake of tau and amyloid beta, but not RAP or ApoE.

Prey-specific toxins provide broad venom activity in cephalopods

The paper identifies prey-specific toxins in cephalopod venom, including neurotensin-mimicking peptides that target fish, revealing an evolutionary strategy for broad venom activity.

Genetic and preclinical evidence implicating chondroitin sulfate as a matritherapeutic target for the treatment of type 2 diabetes

This study identifies chondroitin sulfate as a potential therapeutic target for type 2 diabetes through genetic and preclinical evidence showing its effects on glycemic control and insulin action.

Neuronal loss of Galnt2 in Mice Impairs O-glycosylation and Recapitulates Neurological Features of GALNT2-CDG

This study shows that loss of Galnt2 in mice leads to neurological symptoms similar to GALNT2-CDG and identifies O-glycosylation changes in the brain.