Author

Holger Knaut

NYU Langone HealthORCID 0000-0002-8399-8720Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:zebrafish· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Naoya YamaguchiiD· 4 shared Tugba Colak-ChampollioniD· 2 shared Weiyi QianiD· 2 shared Alex V. NechiporukiD· 1 shared Amanda MaxfieldiD· 1 shared Arwa Al AnberiD· 1 shared Benjamin L. MartiniD· 1 shared Biran WangiD· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersDevelopmental Biology

Naoya YamaguchiORCID

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7 papers

Recent·Most cited

RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration

Hannah M. Olson, Amanda Maxfield, Nicholas L. Calistri, Laura M. Heiser, Weiyi Qian, Holger Knaut, Alex V. Nechiporuk

The paper identifies Mcf2lb as a regulator of rosette integrity during collective cell migration in zebrafish, showing its role in apical constriction and rosette organization.

Development · Jan 1, 2024Peer-reviewedDevelopmental Biology

Pulses of RhoA Signaling Stimulate Actin Polymerization and Flow in Protrusions to Drive Collective Cell Migration

Weiyi Qian, Naoya Yamaguchi, Patrycja Lis, Michael Cammer, Holger Knaut

The paper investigates how RhoA signaling pulses drive collective cell migration in zebrafish by stimulating actin polymerization and flow in protrusions.

Current Biology · Dec 13, 2023Peer-reviewedDevelopmental Biology

A rear-engine drives adherent tissue migration in vivo

Naoya Yamaguchi, Ziyi Zhang, Teseo Schneider, Biran Wang, Daniele Panozzo, Holger Knaut

The paper identifies how the zebrafish posterior lateral line primordium generates forward motion by exerting high stresses at its rear through actin flow coupled to the basement membrane via integrins.

Nature Cell Biology · Feb 1, 2022Peer-reviewedDevelopmental Biology

Knock-in tagging in zebrafish facilitated by insertion into non-coding regions

Daniel S. Levic, Naoya Yamaguchi, Siyao Wang, Holger Knaut, Michel Bagnat

The paper describes a method to generate endogenously tagged zebrafish knock-in lines by inserting fluorescent markers into non-coding regions of genes.

Development · Sep 8, 2021Peer-reviewedDevelopmental Biology

An adhesion code ensures robust pattern formation during tissue morphogenesis

Tony Yu-Chen Tsai, Mateusz Sikora, Peng Xia, Tugba Colak-Champollion, Holger Knaut, Carl‐Philipp Heisenberg, Sean G. Megason

The paper identifies an adhesion code in zebrafish neural progenitors that ensures robust stripe-like pattern formation during spinal cord morphogenesis.

Science · Oct 2, 2020Peer-reviewedDevelopmental Biology

Sox2 and canonical Wnt signaling interact to activate a developmental checkpoint coordinating morphogenesis with mesodermal fate acquisition

Brian A. Kinney, Arwa Al Anber, Richard H. Row, Yu-Jung Tseng, Maxwell D. Weidmann, Holger Knaut, Benjamin L. Martin

The paper identifies a developmental checkpoint involving Sox2 and Wnt signaling that coordinates morphogenesis with mesodermal fate acquisition in zebrafish.

Cell Reports · Oct 1, 2020Peer-reviewedDevelopmental Biology

zGrad: A nanobody-based degron system to inactivate proteins in zebrafish

Naoya Yamaguchi, Tugba Colak-Champollion, Holger Knaut

This paper introduces zGrad, a nanobody-based degron system for inducible and reversible protein inactivation in zebrafish, demonstrating its utility in studying protein function across different spatial and temporal contexts.

eLife · Feb 8, 2019Peer-reviewedDevelopmental Biology