Carsten H. Tischbirek

Whole-organism spatial transcriptomics at single-cell resolution in C. elegans

This paper develops a single-molecule fluorescence in situ hybridization workflow for whole-organism spatial transcriptomics in C. elegans, enabling single-cell resolution and multiplex gene profiling.

Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes

Synaptic MEMOIR maps individual synapses in neuronal projections using protein barcodes, enabling single-synapse resolution in large brain volumes without high-resolution imaging.

Spatial Proofreading Amplification of in situ Transcript and Protein Signals

The paper introduces an enzyme-free signal amplification method for spatial transcriptomics that achieves over 500-fold signal amplification and enables multiplex readout.

The forkhead transcription factor FKH-7/FOXP acts in chemosensory neurons to regulate developmental decision-making

This study identifies a role for FKH-7/FOXP in chemosensory neurons regulating developmental decision-making and links it to autism-associated gene variants.

Integrated spatial genomics in tissues reveals invariant and cell type dependent nuclear architecture

The paper uses integrated spatial genomics to study nuclear architecture in mouse brain cortex cells, revealing chromatin fixed points and cell-type specific organization of nuclear bodies.