Author

Sarah-Lena Offenburger

University of DundeeORCID 0000-0002-8428-0622Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Anton GartneriD· 2 shared Elisabeth JongsmaiD· 1 shared Massimo A. HilliardiD· 1 shared Sean CoakleyiD· 1 shared Theresa Tachie-MensoniD· 1 shared Xue Yan HoiD· 1 shared

Activity by Year

2018-2018 · peak 2/yr

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6 top collaborators · 11 mutual co-author links

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2 shared papersGenetics

Anton GartnerORCID

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2 papers

Recent·Most cited

GeneticsPLoS GeneticsPeer-reviewedJan 18, 2018

Mutations in C. elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment

Sarah-Lena Offenburger, Elisabeth Jongsma, Anton Gartner

This study identifies genes that protect C. elegans dopaminergic neurons from oxidative stress, showing that glit-1, tsp-17, the apoptosis pathway, and crt-1 are required to prevent 6-OHDA-induced neurodegeneration.

25 citations

C. elegansexperimental assay

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedJan 18, 2018

6-OHDA-induced dopaminergic neurodegeneration in C. elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33

Sarah-Lena Offenburger, Xue Yan Ho, Theresa Tachie-Menson…·Anton Gartner

The paper identifies TTR-33 as a neuroprotective factor against 6-OHDA-induced dopaminergic neurodegeneration in C. elegans, showing its role in oxidative stress resistance and interaction with MAPK pathways.

40 citations

C. elegansstatistical model

𝕏 PostBluesky