Author

Theresa Tachie-Menson

Blizard InstituteORCID 0000-0003-0872-4030Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. J. Hughes· 1 shared Anton GartneriD· 1 shared B. R. Thomas· 1 shared E. A. O'Toole· 1 shared Ivan DoykoviD· 1 shared Kevin A. MillsiD· 1 shared L. E. Coppock· 1 shared Massimo A. HilliardiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCell Biology

A. J. Hughes

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 11, 2024

Reduced Filaggrin expression induces dysregulated intracellular signalling in atopic eczema

A. J. Hughes, L. E. Coppock, Theresa Tachie-Menson…·Ryan F.L. O’Shaughnessy

This study identifies dysregulated BMP and ERK1/2/AKT signaling in FLG-deficient keratinocytes and AE biopsies, linking FLG loss to altered desmosomal proteins and suggesting a SMAD1/Filaggrin/AKT therapeutic target.

DOI 10.1101/2024.03.11.584344

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedJan 18, 2018

6-OHDA-induced dopaminergic neurodegeneration in C. elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33

Sarah-Lena Offenburger, Xue Yan Ho, Theresa Tachie-Menson…·Anton Gartner

The paper identifies TTR-33 as a neuroprotective factor against 6-OHDA-induced dopaminergic neurodegeneration in C. elegans, showing its role in oxidative stress resistance and interaction with MAPK pathways.

40 citations

C. elegansstatistical model

𝕏 PostBluesky