Sean Coakley

This study identifies AGEF-1a as a conserved Arf-GEF that maintains axonal integrity by modulating RAB-35 activity in neuron-epidermal attachments in C. elegans.

The paper shows that spectrin forms a periodic scaffold in the epidermis that protects axons from mechanical damage during development and regeneration.

This study shows that mechanosensitive DEG/ENaC channels are essential for dendritic arbor morphogenesis in C. elegans by mediating mechanical feedback during ligand-mediated guidance.

The paper identifies TTR-33 as a neuroprotective factor against 6-OHDA-induced dopaminergic neurodegeneration in C. elegans, showing its role in oxidative stress resistance and interaction with MAPK pathways.