Jun Zhu

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

This study shows that inhibiting PTK6 in triple-negative breast cancer enhances anti-tumor immune responses by increasing CD8+ T and NK cells and reducing immunosuppressive cells.

The paper identifies an epigenomic subtype of SCLC-A defined by NKX2-1 and SOX1 super-enhancers and their functional collaboration.

The paper identifies proinflammatory monocytes/macrophages associated with resistance to PD-1/PD-L1 blockade in urothelial cancer using bulk and single-cell RNA sequencing.

This study identifies shared molecular signatures between chronic fatigue syndrome and other fatiguing illnesses using RNA-sequencing data from blood samples.

This study analyzes genetic variants associated with longevity and age-related diseases to understand their impact on gene expression.

An ensemble of six imputation methods, built through the NCI-CPTAC Proteogenomics DREAM Challenge, fills missing values in labeled LC-MS/MS proteomics data, helping most for low-abundance proteins.

The paper compares gene regulations in 'healthy' and 'common' aging using GTEx data to identify differences and connections with age-related diseases.

The paper identifies 11 methylation-driven key regulators in gastric cancer and shows they contribute to tumor heterogeneity and clinical outcomes.

This paper introduces ANDRU, a human data-driven approach to discover geroprotectors by targeting aging and age-related disease subnetworks, identifying potential targets and compounds in adipose and artery tissues.

The paper identifies VGF as a key regulator of Alzheimer’s disease using multiscale causal network models and validates its protective role in mouse models.

The paper identifies a multiscale temporal regulatory network involving genes that regulate circadian, cell cycle, and aging processes, enriched for signal transduction, metabolism, and stress response genes.