Benno H. ter Kuile

This study shows that overexpression of the Rob regulator in Yersinia enterocolitica accelerates antibiotic resistance development, but is costly without antibiotic selection.

This study shows that ampC gene amplification drives beta-lactam resistance in E. coli, with resistance gene location affecting amplification targets but not the mechanism.

The paper investigates collateral sensitivity and cross-resistance networks in six bacterial species after induced resistance to six antibiotics, finding specific patterns and genetic mechanisms.

This study examines the roles of dinB and katE in E. coli adaptation to amoxicillin, finding that while both genes are involved, their contributions to beta-lactam resistance are distinct.

This study investigates de novo antibiotic resistance acquisition in six bacterial species, finding diverse mutational patterns leading to similar resistance outcomes.

This study examines resistance development to four fluoroquinolones in E. coli, showing varying dependence on the SOS response and distinct mutation profiles.

This study tracks ampC amplification and promoter mutations during de novo amoxicillin resistance development in E. coli, showing amplification occurs after promoter mutations and is facilitated by IS1 transposition.