Yu-ichiro Nakajima

This study shows that aging in Cladonema medusae impairs tissue homeostasis and blastema-mediated regeneration, highlighting shared constraints on regenerative systems across metazoans.

The paper investigates the role of ERK/MAPK and Notch signaling in regulating distinct proliferative populations during jellyfish tentacle regeneration, finding ERK/MAPK promotes RSPC proliferation while Notch controls RHSC differentiation and proliferation balance.

This study identifies Xrp1 as a key driver of damage-induced cellular plasticity in Drosophila enteroendocrine cells, enabling dedifferentiation and re-differentiation during regeneration.

The paper identifies biomechanical modules that govern larval shape diversity across six cnidarian species and shows how manipulating these modules can transform shapes between species.

This study shows that BubR1 and Mad2 regulate midgut remodeling in Drosophila diapause by promoting cell cycle arrest in intestinal stem cells, which is essential for survival under adverse conditions.

This study introduces highly regenerative species-specific genes into Drosophila to improve stem cell function and extend lifespan by enhancing gut barrier functions during aging.

The paper shows nutrient fluctuations induce dedifferentiation of enteroendocrine cells into intestinal stem cells in Drosophila, promoting adaptive intestinal growth.

The paper identifies distinct stem-like cell populations in the jellyfish Cladonema pacificum that contribute to tentacle regeneration through different roles in homeostasis and repair.

The paper introduces an siRNA electroporation method for gene knockdown in jellyfish embryos, demonstrating its effectiveness in two species and revealing conserved developmental pathways.