Catarina Perdigão

The paper identifies a retrograde signaling pathway where UFMylation of ER ribosomes anchors splicing factors at the ER, linking translational stress to nuclear RNA processing and altering membrane-associated gene expression.

This study shows that Alzheimer's disease BIN1 coding variants increase intracellular Aβ by interfering with BACE1 recycling and early endosome enlargement.