UFMylation anchors splicing factors at the ER to reprogram nuclear splicing
Ni Zhan, Ranjith Kumar Papareddy, Bu Erte, Aleksandra S. Anisimova, Catarina Perdigão, Marilyn Tirard, Milica Mihailović, Hasan Akyol, Gülsün Elif Karagöz, Nils Brose, Nicholas A. T. Irwin, Yasin Dagdas
The paper identifies a retrograde signaling pathway where UFMylation of ER ribosomes anchors splicing factors at the ER, linking translational stress to nuclear RNA processing and altering membrane-associated gene expression.
bioRxiv · Mar 30, 2026 · PreprintCell Biology