Kristopher Alan Kilian

Expanding Microgel Parameters to Model the Tumor Microenvironment and Examine Temozolomide Resistance in Glioblastoma

This study uses cell-laden microgels to model GBM tumor microenvironment heterogeneity and screen TMZ resistance in patient-derived xenografts.

Engineered 3D hydrogel model reveals divergence of adhesion-migration balance in Glioblastoma under simulated microgravity

This study shows that simulated microgravity reduces glioblastoma invasion by shifting cells to a more cohesive state, revealing gravity's role in cancer cell plasticity.

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1

This study shows that capillary constrictions reprogram melanoma cells to a tumorigenic cancer stem cell-like state via PIEZO1 mechanosensing.

Gene-Corrected Basal Cells Restore CFTR In Vitro; Transplants Regenerate Epithelium in a Preclinical Sinus Model

Stem cell mechanoadaptation Part B - Microtubule stabilization and substrate compliance effects on cytoskeletal remodeling

This paper investigates how stem cells adapt to mechanical cues by remodeling their cytoskeleton, showing that microtubule stabilization and substrate compliance significantly influence cell mechanics and morphology.

Stem cell mechanoadaptation - Part A - Effect of microtubule stabilization and volume changing stresses on cytoskeletal remodeling

This paper investigates how microtubule stabilization and mechanical compression affect cytoskeletal remodeling in stem cells, showing changes in cell mechanics and structure.

Tuning mechanical milieux of tissue templates and their cellular inhabitants to guide mechanoadaptation

This study investigates how microtubule stabilization with paclitaxel alters MSC mechanoadaptation and lineage commitment by modifying their mechanical environment and cytoskeletal responses.