The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging
Pedro Aguilar-Garrido, María Velasco‐Estevez, Miguel Ángel Navarro-Aguadero, María Hernández‐Sánchez, Prerna Malaney, Xiaroui Zhang, Marisa J.L. Aitken, Álvaro Otero, Marta Ibáñez-Navarro, Alejandra Ortiz-Ruiz, Diego Megı́as, Manuel Pérez‐Martínez, Gadea Mata, Jesús Gómez, Orlando Domı́nguez, , Miguel Gallardo
This study identifies Hnrnpk as a master regulator of nucleolar stress and ribosome impairment, linking nucleolar abnormalities to aging and bone marrow failure.
bioRxiv · Mar 7, 2023 · PreprintMolecular Biology