Author

Orlando Domı́nguez

Spanish National Cancer Research CentreORCID 0000-0002-7016-6490Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Álvaro OteroiD· 2 shared Alba De MartinoiD· 1 shared Alejandra Ortiz-RuiziD· 1 shared Antonio CubilloiD· 1 shared Carmen Blanco‐AparicioiD· 1 shared Daniel LiethaiD· 1 shared Diego Megı́asiD· 1 shared Eduardo J. CaleirasiD· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Álvaro OteroORCID

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2 papers

Recent·Most cited

The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

Pedro Aguilar-Garrido, María Velasco‐Estevez, Miguel Ángel Navarro-Aguadero, María Hernández‐Sánchez, Prerna Malaney, Xiaroui Zhang, Marisa J.L. Aitken, Álvaro Otero, Marta Ibáñez-Navarro, Alejandra Ortiz-Ruiz, Diego Megı́as, Manuel Pérez‐Martínez, Gadea Mata, Jesús Gómez, Orlando Domı́nguez, , Miguel Gallardo

This study identifies Hnrnpk as a master regulator of nucleolar stress and ribosome impairment, linking nucleolar abnormalities to aging and bone marrow failure.

bioRxiv · Mar 7, 2023 · PreprintMolecular Biology

Whole-exome sequencing of plasma cell-free DNA portrays the somatic mutation landscape of refractory metastatic colorectal cancer and enables the discovery of mutated KDR/VEGFR2 receptors as modulators of anti-angiogenic therapies.

Rodrigo Almeida Toledo, Elena Garralda, Maria Mitsi, Tirso Pons, Jorge Monsech, Estela Vega, Álvaro Otero, Maria Isabel Albarran, Natalia Baños, Yolanda Durán, Victoria Bonilla, Francesca Sarno, Marta Camacho‐Artacho, Tania Sánchez‐Pérez, Sofia Hidalgo Perea, , Manuel M. Hidalgo

This study uses whole-exome sequencing of plasma cell-free DNA to analyze somatic mutations in metastatic colorectal cancer and identifies KDR/VEGFR2 mutations affecting anti-angiogenic therapy response.

bioRxiv · Aug 28, 2017 · PreprintGenomics