Brian C. Glancy

This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.

This paper provides a comprehensive protocol for quantifying cellular organelles using light microscopy and Fiji/ImageJ, enabling precise, high-throughput, and statistically comparable measurements across different samples.

The paper validates a method to quantify 3D mitochondrial network morphology in mouse skeletal muscle and applies it to terminal Schwann cells, showing increased fragmentation in dystrophic muscle.

This study shows that overexpressing ChR2-EYFP in skeletal muscle causes contractile dysfunction, while ChR2-only mice show normal function, highlighting the need for alternative optogenetic models.

This study examines changes in myofibril size, shape, and connectivity in aging muscle across mice and humans, finding increased connectivity and variable size/shape changes depending on muscle type.