Author

Prasanna Katti

Indian Institute of Science Education and Research, TirupatiORCID 0000-0002-6748-3460Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Physiology· 2 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Assay:imaging· 5 Organism:human· 4 Organism:mouse· 3 Research Focus:metabolism & bioenergetics· 2 Approach:microscopy & imaging analysis· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Antentor Othrell Hinton Jr.iD· 7 shared Prasanna VenkhateshiD· 7 shared Amber CrabtreeiD· 6 shared Andrea Gail MarshalliD· 6 shared Annet KiraboiD· 6 shared Edgar Garza LopeziD· 5 shared Oleg KovtuniD· 5 shared Sepiso Kenias MasengaiD· 5 shared

Activity by Year

2024-2026 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersCell Biology

Antentor Othrell Hinton Jr.ORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Stress-Encoded Mitochondrial Plasticity: ATF4 Control of Mega-Mitochondria and Nanotunnel Communication

Amber Crabtree, Suraj Thapliyal, Mohd Mabood Khan, Edgar Garza Lopez, Andrea Gail Marshall, Calixto Pablo Hernandez Perez, Oleg Kovtun, Jenny C. Schafer, Dea Pulatani, Yuho Kim, Sepiso Kenias Masenga, Annet Kirabo, Jeremiah Afolabi, Melanie R. McReynolds, Renata Oliveira Pereira, , Antentor Othrell Hinton Jr.

This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.

bioRxiv · May 5, 2026 · PreprintCell Biology

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

Prasanna Katti, Praveena Prasad, Sepiso Kenias Masenga, Prasanna Venkhatesh, Zer Vue, Andrea Gail Marshall, Benjamin Rodriguez, Han Le, Edgar Garza Lopez, Alexandria C. Murphy, Brenita C. Jenkins, Ashlesha A. Kadam, Jianqiang Shao, Amber Crabtree, Pamela Martin, , Antentor Othrell Hinton Jr.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Aging Cell · May 1, 2026Peer-reviewedPhysiology

Three-dimensional electron microscopy uncovers mitochondrial network remodeling in residual triple negative breast cancer persisting after conventional chemotherapy treatments.

Mariah J. Berner, Heather K. Beasley, Benjamin Rodriguez, Audra Lane, Steven W. Wall, Andrea Gail Marshall, Zer Vue, Larry Vang, Mokryun L. Baek, Mason Killion, Faben Zeleke, Bryanna Shao, Dominique Parker, Autumn Peterson, Julie A. Rhoades Sterling, , Gloria Vittone Echeverria

This study uses 3D electron microscopy to analyze mitochondrial network changes in residual triple negative breast cancer after chemotherapy, revealing structural remodeling and lipid droplet interactions associated with chemoresistance.

iScience · Apr 24, 2026Peer-reviewedCancer Biology

The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease

Bryanna Shao, Bartosz Kula, Han Le, Prasanna Venkhatesh, Prasanna Katti, Andrea G. Marshall, Siddharth Chittaranjan, Suraj Thapilyal, Namdar Hari Kalpana, C. Nivedya, Adam Roszczyk, Harrison Mobley, Mason Killion, Emelina St John, Pamela Martin, , Nathan Smith

This study investigates how MICOS disruption affects mitochondrial structure and function in neurons vulnerable to Alzheimer's disease, linking these changes to early mitochondrial dysfunction and neuronal vulnerability.

bioRxiv · Apr 1, 2026 · PreprintNeuroscience

ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle

Amber Crabtree, Mohd Mabood Khan, Estêvão Scudese, Calixto Pablo Hernandez Perez, Prasanna Venkhatesh, Andrea Gail Marshall, Benjamin Rodriguez, Edgar Garza Lopez, Okwute Michael Ochayi, Estélio Henrique Martin Dantas, Pamela Martin, Matheus Baffi, Fabiana Rodrigues Scartoni, Margaret Mungai, Kit Neikirk, , Antentor Othrell Hinton Jr.

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

bioRxiv · Mar 30, 2026 · PreprintCell Biology

Light Microscopy-Based Organelle Quantification: A Comprehensive Protocol

Suraj Thapliyal, Hari Kalpana Namdar, Ronald K. McMillan, Jermiah Afolabi, Andrea Gail Marshall, Prasanna Venkhatesh, Ravi Kumar Pujala, Antentor Othrell Hinton Jr., Hailey A. Parry, Brian C. Glancy, Prasanna Katti

This paper provides a comprehensive protocol for quantifying cellular organelles using light microscopy and Fiji/ImageJ, enabling precise, high-throughput, and statistically comparable measurements across different samples.

Current Protocols · Feb 27, 2026Peer-reviewedCell Biology

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

Sepiso Kenias Masenga, Alexandria C. Murphy, Prasanna Venkhatesh, Zer Vue, Ashlesha A. Kadam, Andrea Gail Marshall, Benjamin Rodriguez, Estêvão Scudese, Brenita C. Jenkins, Amber Crabtree, Praveena Prasad, Edgar Garza Lopez, Han Le, Ky’Era V. Actkins, Elma Zaganjor, , Antentor Othrell Hinton Jr.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

bioRxiv · Jun 20, 2024 · PreprintPhysiology