Notch signaling in germ line stem cells controls reproductive aging in C. elegans
Zuzana Kocsisova, Elena D. Bagatelas, Jesús M. Santiago-Borges, Hanyue Cecilia Lei, Brian M. Egan, Matthew C. Mosley, Daniel L. Schneider, Tim Schedl, Kerry Kornfeld
This study identifies Notch signaling in the distal germline as a root cause of reproductive aging in C. elegans by showing that ectopic expression of the Notch effector gene SYGL-1 delays aging.
bioRxiv · Mar 4, 2022 · PreprintGenetics