Matthew C. Mosley

Environmental NaCl affects C. elegans development and aging

This study shows that NaCl in standard C. elegans growth medium accelerates aging and reduces lifespan, with toxicity increasing with age and activating stress response pathways.

The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging

The paper shows captopril extends lifespan in worms and mice by inhibiting ACN-1, which regulates dauer formation and interacts with daf genes.

Notch signaling in germ line stem cells controls reproductive aging in C. elegans

This study identifies Notch signaling in the distal germline as a root cause of reproductive aging in C. elegans by showing that ectopic expression of the Notch effector gene SYGL-1 delays aging.