Brian M. Egan

This study shows that tryptophan restores recovery competence after starvation in C. elegans by countering unrestrained mTOR activity, independent of lysosomal amino acid sensing.

This study shows that NaCl in standard C. elegans growth medium accelerates aging and reduces lifespan, with toxicity increasing with age and activating stress response pathways.

The paper shows captopril extends lifespan in worms and mice by inhibiting ACN-1, which regulates dauer formation and interacts with daf genes.

This study identifies Notch signaling in the distal germline as a root cause of reproductive aging in C. elegans by showing that ectopic expression of the Notch effector gene SYGL-1 delays aging.