Author

Hanyue Cecilia Lei

Washington University in St. LouisORCID 0000-0001-5944-1167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Brian M. EganiD· 1 shared Carla M. YuedeiD· 1 shared Chao‐Cheng KuoiD· 1 shared Daniel L. SchneideriD· 1 shared Elena D. BagatelasiD· 1 shared Jesús M. Santiago-BorgesiD· 1 shared Jordan G. McCalliD· 1 shared Kerry KornfeldiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Brian M. EganORCID

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2 papers

Recent·Most cited

NeuroscienceMolecular PsychiatryPeer-reviewedSep 16, 2025

Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area

Hanyue Cecilia Lei, Kyle E. Parker, Chao‐Cheng Kuo…·Shin‐ichiro Imai

This study shows that aging reduces motivation in mice by decreasing Bdnf expression in the ventral tegmental area, and that this effect can be replicated by Bdnf knockdown in young mice.

8 citations

mousestatistical model

𝕏 PostBluesky

GeneticsbioRxivPreprintMar 4, 2022

Notch signaling in germ line stem cells controls reproductive aging in C. elegans

Zuzana Kocsisova, Elena D. Bagatelas, Jesús M. Santiago-Borges…·Kerry Kornfeld

This study identifies Notch signaling in the distal germline as a root cause of reproductive aging in C. elegans by showing that ectopic expression of the Notch effector gene SYGL-1 delays aging.

4 citations

C. elegansexperimental assay

𝕏 PostBluesky