Nathan Harmston

The paper uses single-cell RNA sequencing to study D. pseudoobscura testes, identifying transcriptional differences between eusperm and parasperm lineages during spermatogenesis.

The paper identifies Wnt-regulated genes repressed by or independent of β-catenin in a cancer model, revealing a cis-regulatory motif involved in repression.

This study combines stem cell rejuvenation and senescent cell clearance to synergistically extend lifespan and improve healthspan in organisms.

This study identifies a non-canonical Raf function in Drosophila embryogenesis that is essential for dorsal-ventral patterning, independent of the MAPK cascade.

The paper identifies and functionally validates Wnt-regulated lncRNAs using in vivo models and CRISPRi screens, finding more functional lncRNAs in vivo than in vitro.

This paper develops a reproducible method to generate cardiac muscle progenitors from human stem cells using laminin-221, which can form human heart muscle in vivo after transplantation.

The paper shows Wnt/STOP signaling regulates ribosome biogenesis in Wnt-addicted cancers by modulating transcription and protein abundance of key factors.

The paper develops an in vivo Drosophila assay to distinguish Wnt pathway transcriptional responses, identifying gene sets regulated by β-catenin, TCF, and non-canonical Wnt4.

ABBA detects differentially methylated regions in WGBS data, identifies disease-associated methylation changes, and proposes a mechanism for glomerulonephritis via Ifitm3 promoter hypermethylation.