Sarah R. Langley

This study examines how aging interacts with TSPO's immunomodulatory role in mouse hippocampus, showing aging reverses TSPO knockout effects and exacerbates inflammation.

This paper identifies PRMT5 as a regulator of HTT mRNA splicing and alternative polyadenylation, showing that its inhibition reduces full-length HTT protein levels by promoting premature termination and cleavage.

This study identifies splicing dysregulation in RNA processing and neuronal function genes in early and late-stage Huntington's disease using an isogenic neuronal cell model and post-mortem data.

This study evaluates connectivity methods for drug repurposing by testing their robustness to noise using gene expression data from the LINCS database.

This study shows that Ermin deficiency causes myelin abnormalities and inflammation, leading to neurological deficits and increased susceptibility to demyelination, suggesting it as an 'inside-out' model for inflammatory dysmyelination.

This study shows that TSPO regulates mitochondrial metabolism and phagocytosis in microglia, and that targeting mitochondrial HK could improve phagocytosis in Alzheimer's disease.

The paper shows that the habenula clock modulates circadian variation in danger prediction, affecting anxiety-like responses to alarm pheromones in zebrafish.

This study shows that expanded CAG repeats in HTT disrupt neural progenitor expansion and differentiation in human cerebral organoids, suggesting abnormal neurodevelopment in Huntington disease.

The paper identifies translational regulators of fibrogenic genes in human cardiac fibroblasts and shows their role in cardiac fibrosis through ribosome profiling and RNA-binding protein analysis.

ABBA detects differentially methylated regions in WGBS data, identifies disease-associated methylation changes, and proposes a mechanism for glomerulonephritis via Ifitm3 promoter hypermethylation.