Erik J. Soderblom

Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis.

This study identifies Nedd4l-mediated ubiquitination of NL2 as essential for astrocyte morphogenesis during development.

In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of a-synuclein Toxicity in Dopamine Neurons.

The paper uses in vivo proteomics and CRISPR screening to identify STXBP1 as a protective factor against α-synuclein toxicity in dopamine neurons in Parkinson's disease models.

Regulation of trehalose biosynthesis and thermotolerance by the Cryptococcus neoformans HECT E3 ubiquitin ligase Rsp5

This study shows that Rsp5 ubiquitination regulates trehalose biosynthesis in C. neoformans, enhancing thermotolerance and salt stress resistance.

Protein Language Model-Aligned Spectra Embeddings for De Novo Peptide Sequencing

PLMNovo improves de novo peptide sequencing by aligning spectrum and peptide embeddings using pre-trained protein language models.

Rpl13a snoRNAs Downregulate Smooth Muscle Cell COX4I2 and Promote Neointimal Hyperplasia

This study shows that Rpl13a snoRNAs increase SMC ROS levels by reducing COX4I2 expression, leading to neointimal hyperplasia.

Dynamic regulation of Sec24C by phosphorylation and O-GlcNAcylation during cell cycle progression

This study identifies phosphorylation and O-GlcNAcylation of Sec24C as mechanisms regulating its mitotic dispersal and potential role in equal partitioning of endomembranes.

Dynamic regulation of the COPII interactome and collagen trafficking by site-specific glycosylation of Sec24D

The paper shows that O-GlcNAcylation of Sec24D regulates collagen trafficking by modulating its interactome and interaction with myoferlin in human cells and zebrafish.

Intestinal enteroendocrine cell subtype differentiation and hormone production in zebrafish

The paper identifies EEC subtypes and hormone production in zebrafish using single-cell RNA sequencing and mass spectrometry, revealing distinct precursor relationships.

Presynaptic Rac1 in the hippocampus selectively regulates working memory

This study shows that presynaptic Rac1 signaling selectively regulates spatial working memory, with distinct effects on synaptic vesicles and morphology compared to postsynaptic Rac1 inhibition.

Protein CoAlation on TXNRD2 regulates mitochondrial thioredoxin system to protect against ferroptosis

This study identifies CoA-mediated post-translational modification of TXNRD2 as a novel mechanism regulating the mitochondrial thioredoxin system to protect against ferroptosis.

Heat Shock Proteins Function as Signaling Molecules to Mediate Neuron-Glia Communication During Aging

The paper identifies a novel neuron-glia communication mechanism involving heat shock proteins transmitted via extracellular vesicles, which activate glial pathways to protect against aging-related decline.

Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

Proximity Analysis of Native Proteomes Reveals Interactomes Predictive of Phenotypic Modifiers of Autism and Related Neurodevelopmental Conditions

The paper develops a proximity proteomics method in mice to identify protein interactions relevant to autism, revealing new genetic risk factors and functional interactions.

Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

This study identifies Rac1 and Arp2/3 as key regulators of presynaptic plasticity through proteomic analysis and shows their coupling to action potentials via calcium influx.