Tien Minh Phan

Scaffold Affinity Tunes Biomolecular Condensate Function

This study shows that scaffold binding affinity determines condensate phase behavior, dynamics, and biochemical output in vitro and in human cells.

The role of electrostatic interactions in the phase separation of HP1α and its protein binding partners

This study investigates how electrostatic interactions influence HP1α phase separation and its interactions with binding partners, showing that these interactions modulate HP1's properties and functions.

Multiscale simulations elucidate the mechanism of polyglutamine aggregation and the role of flanking domains in fibril polymorphism

This study uses multiscale simulations to investigate polyglutamine aggregation mechanisms and how the N17 flanking domain influences fibril polymorphism in Huntingtons disease.

Uncovering the molecular interactions underlying MBD2 and MBD3 phase separation

This study investigates the molecular interactions driving phase separation in MBD2 and MBD3 proteins, revealing distinct mechanisms despite their structural similarity.

Transient interdomain interactions modulate the monomeric structural ensemble and self-assembly of Huntingtin Exon 1

This study uses molecular dynamics simulations to show that transient interdomain interactions in Httex1 modulate its structural ensemble and self-assembly, contributing to aggregation in Huntington's disease.

Capturing the Conformational Heterogeneity of HSPB1 Chaperone Oligomers at Atomic Resolution

This paper characterizes the structure and dynamics of HSPB1 oligomers using biophysical and computational methods, revealing conformational heterogeneity and domain-specific interactions.