Alexander P. Plonski

This paper introduces a degron decoy system that uses pathological seeding to clear multimeric α-synuclein by co-aggregating with oligomers and enabling degradation via a small molecule trigger.

This paper characterizes the structure and dynamics of HSPB1 oligomers using biophysical and computational methods, revealing conformational heterogeneity and domain-specific interactions.

The paper evaluates how accurately homology models predict small molecule binding by comparing docking results to experimental structures.