Author

Raymond F. Berkeley

Scripps Research InstituteORCID 0000-0002-3567-1547Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Mark A. HerzikiD· 3 shared Alexander P. PlonskiiD· 1 shared Armin Foroughi· 1 shared B. CookiD· 1 shared Benjamin F. CravattiD· 1 shared Bruno N. MelilloiD· 1 shared Daniel JiiD· 1 shared Evert NjomeniD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

Mark A. HerzikORCID

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Author profile →

3 papers

Recent·Most cited

Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex

Rachel E. Hayward, Raymond F. Berkeley, Zijian Gao, Maximilian Garhammer, Marc A. Morizono, Evert Njomen, Haoxin Li, Kristen E. DeMeester, Victor Cociorva, Mark A. Herzik, F. Ulrich Hartl, Bruno N. Melillo, Benjamin F. Cravatt

The paper identifies inhibitors of the GRPEL1-HSPA9 chaperone complex using tryptoline stereoprobes and shows they target non-orthosteric sites.

bioRxiv · Oct 20, 2025 · PreprintBiochemistry

ANTIDOTE: A Metadata-Driven Neural Network for Improving CryoEM 3-D Particle Sorting

Raymond F. Berkeley, B. Cook, Daniel Ji, Armin Foroughi, Yifei He, Maxwell J. Bachochin, Mark A. Herzik

ANTIDOTE improves cryoEM particle sorting by using metadata-driven neural networks, enhancing reconstruction quality and reducing manual curation efforts.

bioRxiv · Oct 6, 2025 · PreprintBiophysics

Capturing the Conformational Heterogeneity of HSPB1 Chaperone Oligomers at Atomic Resolution

Raymond F. Berkeley, Alexander P. Plonski, Tien Minh Phan, Kristof Grohe, Lukas Becker, Sebastian Wegner, Mark A. Herzik, Jeetain Mittal, Galia T. Debelouchina

This paper characterizes the structure and dynamics of HSPB1 oligomers using biophysical and computational methods, revealing conformational heterogeneity and domain-specific interactions.

Journal of the American Chemical Society · Mar 27, 2025Peer-reviewedBiophysics