Author

David S. Bouvier

University of LuxembourgORCID 0000-0002-8630-1044Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 5 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Assay:protein structure· 2

Frequent Co-Authors

Naguib MechawariD· 4 shared Alexander SkupiniD· 3 shared Félicia JeannelleiD· 3 shared Gaël Paul HammeriD· 3 shared Michel Guy André MittelbronniD· 3 shared Mónica Miranda de la MazaiD· 3 shared Dominique MiraultiD· 2 shared Luis SalamancaiD· 2 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersNeuroscience

Naguib MechawarORCID

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Author profile →

6 papers

Recent·Most cited

Disease-specific tangle immunophenotypes distinguish hippocampal vulnerability in Alzheimers disease and Parkinsons disease dementia

Sophie Schreiner, Mónica Miranda de la Maza, Gaël Paul Hammer, Félicia Jeannelle, Morgane Darricau, Dominique Mirault, Naguib Mechawar, Netherlands Brain Bank, Michel Guy André Mittelbronn, David S. Bouvier

The paper identifies disease-specific tau immunophenotypes in hippocampal subfields of Alzheimer's disease and Parkinson's disease dementia.

bioRxiv · Aug 22, 2026 · PreprintNeuroscience

Glypican-5 delineates spatially distinct astrocyte and neuronal populations in the human hippocampus and is selectively remodelled in Alzheimer's disease

Félicia Jeannelle, Mónica Miranda de la Maza, Sophie Schreiner, Gaël Paul Hammer, Dominique Mirault, Naguib Mechawar, Brainbank Neuro-CEB Neuropathology Network, Netherlands Brain Bank, Michel Guy André Mittelbronn, David S. Bouvier

The paper maps Glypican-5 expression in human hippocampus and shows its disease-specific remodeling in Alzheimer's disease.

bioRxiv · Aug 19, 2025 · PreprintNeuroscience

DJ-1 mediates regulation of metabolism and immune response in Parkinsons disease astrocytes and Glioblastoma cells

Pauline Mencke, Jochen Ohnmacht, Félicia Jeannelle, Adrien J Ries, Mónica Miranda de la Maza, Mathilde M. Ullrich, François Massart, Patrycja Mulica, Katja Badanjak, Zoé Hanss, Arkadiusz Rybicki, Paul M. A. Antony, Sylvie Delcambre, Giuseppe Arena, Gérald Cruciani, , Ibrahim Boussaad

This study shows DJ-1 affects metabolism and immune response differently in Parkinson's disease and glioblastoma cells, with antioxidant treatment rescuing PD-related phenotypes.

bioRxiv · Oct 31, 2024 · PreprintNeuroscience

Mechanistic multiscale modelling of energy metabolism in human astrocytes indicates morphological effects in Alzheimer's Disease

Sofia Farina, Valérie Voorsluijs, Sonja Fixemer, David S. Bouvier, Susanne Claus, Stéphane Bordas, Alexander Skupin

The paper develops a multiscale metabolic model of human astrocytes to show how morphological changes in Alzheimer's Disease affect their metabolic function and support capacity.

bioRxiv · Jul 21, 2022 · PreprintSystems Biology

Concomitant AD and DLB pathologies shape subfield microglia responses in the hippocampus

Sonja Fixemer, Corrado Ameli, Gaël Paul Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean‐Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Guy André Mittelbronn, David S. Bouvier

This study examines how Alzheimer's and Dementia with Lewy Bodies pathologies influence microglia responses in hippocampal subfields, finding distinct patterns in disease severity and microglial morphology.

bioRxiv · Jan 6, 2022 · PreprintNeuroscience

MIC-MAC: High-throughput analysis of three-dimensional microglia morphology in mammalian brains

Luis Salamanca, Naguib Mechawar, Keith Kazuo Murai, Rudi Balling, David S. Bouvier, Alexander Skupin

The paper develops a method to analyze 3D microglia morphology in mammalian brains using imaging, revealing species- and disease-specific morphological differences in mouse and human samples.

bioRxiv · Aug 10, 2018 · PreprintNeuroscience