Naguib Mechawar

This study validates and compares TSE and GRASE techniques for myelin water imaging in postmortem human brains, showing moderate to strong agreement between the sequences.

This study quantifies how formaldehyde fixation affects MRI metrics in postmortem human brains over time and provides a framework to correct for these effects.

The paper identifies disease-specific tau immunophenotypes in hippocampal subfields of Alzheimer's disease and Parkinson's disease dementia.

The paper identifies spatially localized astrocytic dysfunction in depression using multi-omics data and shows its role in disease pathology.

This study examines how prolonged formalin fixation affects immunohistochemical and histochemical stains in postmortem human brains, finding decreased staining for specific markers over time.

This study characterizes the lipid composition of the human uncinate fasciculus and finds age-related changes but no significant differences related to depression or childhood abuse.

This study characterizes the human uncinate fasciculus using multimodal approaches, finding no group differences in histology but identifying differentially expressed genes and age-related changes.

The paper shows that serotonergic neurons in the dorsal raphe nucleus adjust oxygen utilization in response to traumatic stress, with distinct patterns linked to susceptibility or resilience.

This study identifies widespread gene expression changes in the neurovascular unit of female depressed suicides with childhood abuse histories, highlighting key regulators like KLF2 and KLF4.

The paper develops and validates a novel sf-CARS system with AxonDeepSeg to analyze UF ultrastructure in human postmortem brain tissue, finding mean axon diameter and myelin thickness.

The paper maps Glypican-5 expression in human hippocampus and shows its disease-specific remodeling in Alzheimer's disease.

The paper validates the presence of neuronal cell bodies in human long-range white matter tracts, finding higher densities in the uncinate fasciculus compared to other regions.

This study identifies differential chromatin architecture and risk variants in specific brain cell types associated with major depressive disorder.

This study develops a method to isolate oligodendrocyte-lineage cells from postmortem brain tissue and finds age-related gene expression changes and a correlation between oligodendrocyte density and myelin area in the basolateral amygdala.

The paper investigates BMAL1 expression in human and mouse microglia using multiple methods and finds minimal or absent expression, with epigenetic factors likely suppressing it.

The paper investigates how childhood abuse affects the locus coeruleus-noradrenergic system in post-mortem brain samples, finding reduced neuron density and differential gene expression in resilient individuals.

This study identifies dopamine-dependent transcriptional changes in the dorsal hippocampal formation during pregnancy and postpartum, showing how dopamine modulates neural plasticity and behavior.

This study characterizes molecular changes in the ventral striatum of individuals with cocaine use disorder using multi-omics and single-cell approaches, identifying perturbations in metabolic pathways and cell-type-specific alterations.

The paper investigates how childhood abuse affects microglial markers and perineuronal nets in the ventromedial prefrontal cortex of individuals who died by suicide.

The paper uses spatial transcriptomics and FISH to analyze adult hippocampal neurogenesis in the human dentate gyrus across ages, finding few neural stem cell markers but significant DCX expression with mixed inhibitory and excitatory phenotypes.

The paper describes a postmortem MRI protocol for the Douglas-Bell Canada Brain Bank to acquire high-resolution images while preserving tissue for histological analysis.

This study identifies proteomic changes in the human male olfactory bulb associated with depression, highlighting astrocytic dysfunction and species-specific differences in mouse models.

The paper compares cerebellar astrocytes and Purkinje cells across humans, macaques, and mice, finding species-specific differences in distribution, size, and marker expression.

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

This study examines CS disaccharide sulfation patterns in human and mouse brains, finding regional and species-specific differences and showing ELS does not affect PNN labeling patterns.

The paper introduces a method to isolate intact microvessels from frozen tissue and uses multi-omics to characterize the neurovascular unit.

The paper examines changes in substance P, NPY, and their receptors in major depression by analyzing transcript levels in brain regions of suicide victims and controls.

This study shows that early-life stress alters microglial transcriptome and function in mice, affecting phagocytic capacity and gene expression in adulthood.

This study examines how Alzheimer's and Dementia with Lewy Bodies pathologies influence microglia responses in hippocampal subfields, finding distinct patterns in disease severity and microglial morphology.