Rudi Balling

The paper presents a computational framework for analyzing SARS-CoV-2-host interactions to identify drug targets and model disease mechanisms.

The paper analyzes sncRNA-seq data from the PPMI cohort to identify miRNAs associated with Parkinson's disease progression and systemic inflammation.

This study examines age-related changes in the nigro-striatal circuit across three mouse strains, revealing strain-specific differences in dopaminergic neuron integrity and highlighting the importance of considering strain and age in Parkinson's disease research.

The paper analyzes mitochondria-mitochondria interaction networks in Parkinson's disease and finds altered topological patterns that correlate with clinical scores and can distinguish patients from controls.

The paper identifies Pttg1 as a key regulator of gene expression variation in mouse ventral midbrain across aging, showing its role in transcriptome shifts and cell-type-specific changes.

The paper investigates the role of alpha-synuclein spreading and inclusions in Parkinson disease using a mouse model, finding that neurodegeneration and microgliosis occur independently of inclusions.

The paper identifies Col4a6 as a genetic regulator of striatal dopamine levels and axonal branching in mice through QTL mapping and RNA-seq analysis.

The paper models the ROS regulatory network to show how its dysfunction contributes to age-related diseases like Parkinson's and suggests potential therapeutic interventions.

The paper develops a method to analyze 3D microglia morphology in mammalian brains using imaging, revealing species- and disease-specific morphological differences in mouse and human samples.