Dominique Mirault

T2 relaxometry for myelin water fraction: an ex vivo brain imaging study

This study validates and compares TSE and GRASE techniques for myelin water imaging in postmortem human brains, showing moderate to strong agreement between the sequences.

Spatiotemporal trajectories of formaldehyde fixation effects on quantitative MRI in postmortem human brains

This study quantifies how formaldehyde fixation affects MRI metrics in postmortem human brains over time and provides a framework to correct for these effects.

Disease-specific tangle immunophenotypes distinguish hippocampal vulnerability in Alzheimers disease and Parkinsons disease dementia

The paper identifies disease-specific tau immunophenotypes in hippocampal subfields of Alzheimer's disease and Parkinson's disease dementia.

Effects of prolonged fixation on vascular biomarkers in postmortem human brains

This study examines how prolonged formalin fixation affects immunohistochemical and histochemical stains in postmortem human brains, finding decreased staining for specific markers over time.

Glypican-5 delineates spatially distinct astrocyte and neuronal populations in the human hippocampus and is selectively remodelled in Alzheimer's disease

The paper maps Glypican-5 expression in human hippocampus and shows its disease-specific remodeling in Alzheimer's disease.

Evidence of microglial involvement in the childhood abuse-associated increase in perineuronal nets in the ventromedial prefrontal cortex

The paper investigates how childhood abuse affects microglial markers and perineuronal nets in the ventromedial prefrontal cortex of individuals who died by suicide.

The Douglas Bell Canada Brain Bank Post-mortem Brain Imaging Protocol

The paper describes a postmortem MRI protocol for the Douglas-Bell Canada Brain Bank to acquire high-resolution images while preserving tissue for histological analysis.