Npbwr1 signaling mediates fast antidepressant action
Gregor Stein, Janine S. Aly, Lisa De Lange, Annamaria Manzolillo, Konstantin Riege, Anna Brancato, Christian Andreas Hübner, Gustavo Turecki, Steve Hoffmann, Olivia Engmann
This study identifies Npbwr1 as a key regulator of depressive-like symptoms and shows that its antagonist CYM50769 rapidly alleviates these symptoms in mice.
bioRxiv · Feb 2, 2024 · PreprintNeuroscience