Olivia Engmann

Systemic stress states are reversed by NPBWR1 inhibition

This study identifies chronic stress as a systemic molecular state across tissues in mice, showing that NPBWR1 inhibition reverses stress-related changes in multiple organs and sexes.

Aging reprograms the response to chronic stress

This study shows that chronic stress accelerates brain aging in young mice but activates age-specific anti-aging programs in old mice.

Transthyretin orchestrates vitamin B12-induced stress resilience

This study identifies Transthyretin as a sex-specific target of vitamin B12 that influences stress resilience through DNA methylation changes in the prefrontal cortex.

Inactivation of the DREAM complex mimics the molecular benefits of sleep.

This study identifies the DREAM complex as a mediator of sleep and circadian benefits, showing that inhibiting DREAM can mimic sleep's cellular repair effects in sleep-deprived organisms.

Npbwr1 signaling mediates fast antidepressant action

This study identifies Npbwr1 as a key regulator of depressive-like symptoms and shows that its antagonist CYM50769 rapidly alleviates these symptoms in mice.