Lisa De Lange

This study identifies chronic stress as a systemic molecular state across tissues in mice, showing that NPBWR1 inhibition reverses stress-related changes in multiple organs and sexes.

This study shows that chronic stress accelerates brain aging in young mice but activates age-specific anti-aging programs in old mice.

This study identifies Transthyretin as a sex-specific target of vitamin B12 that influences stress resilience through DNA methylation changes in the prefrontal cortex.

This study identifies Npbwr1 as a key regulator of depressive-like symptoms and shows that its antagonist CYM50769 rapidly alleviates these symptoms in mice.