Stability of orb mRNA in Drosophila ovaries is regulated by cis-regulatory elements in the three prime untranslated region and influences germ cell specification
Mariya V. Zhukova, Konstantin V. Yakovlev, Justinn Barr, Rudolf A. Gilmutdinov, Anna V. Tvorogova, Paul D. Schedl, Yulii V. Shidlovskii
This study shows that CPE motifs in the orb 3UTR regulate mRNA stability and are essential for oocyte specification in Drosophila, while their absence leads to nurse cell development.
bioRxiv · Dec 11, 2025 · PreprintCell Biology