Paul D. Schedl

The paper investigates how shared Su(Hw) binding sites between TAD boundaries affect long-distance regulation and physical interactions in Drosophila.

The paper introduces Domino, a deep learning framework that models sequence-to-function relationships to uncover the context-specific grammar of Drosophila chromatin insulation.

The paper shows that Wunen(s) inhibit Hedgehog signaling in Drosophila PGCs by affecting Smo localization and lipid metabolism, preventing premature clumping.

The paper identifies distal and interchromosomal chromatin interactions in T cells using a new algorithm and links them to gene regulation through epigenomic analysis.

This study shows that CPE motifs in the orb 3UTR regulate mRNA stability and are essential for oocyte specification in Drosophila, while their absence leads to nurse cell development.

The paper investigates the homie insulator in Drosophila to understand its substructure and functional properties, revealing that specific sub-elements contribute to different insulating and long-range pairing activities.

This study tests two models for TAD boundary formation in flies and finds that boundary pairing, not loop extrusion, determines TAD endpoints.

The paper investigates how loop topology in Drosophila TADs affects physical and regulatory landscapes by replacing boundaries and analyzing the resulting structural and functional changes.

The paper shows that lncRNA read-through from the Fub-1 boundary in Drosophila inactivates its insulating activity in PS6/A1.

The paper investigates bypass activity in Drosophila Abd-B regulatory boundaries, finding that bypass elements must be in the domain driving Abd-B expression and that bypass activity is location-dependent.

The paper investigates how transcriptional readthrough affects boundary function in Drosophila BX-C, finding that it can impair boundary activity and influence enhancer function.

The paper shows that Zelda and CLAMP are required for proper germline/soma distinction in Drosophila embryos by regulating PGC determinant sequestration and preventing their spread to somatic nuclei.

The paper identifies MSL2 recruitment to a specific histone locus in D. virilis and shows differences in cis-regulatory mechanisms compared to D. melanogaster.

The paper shows that redundant enhancers in the iab-5 domain cooperate with iab-4 and iab-6 domains to activate Abd-B in A5 and A6 abdominal segments of Drosophila.

The paper investigates the role of the orb2 gene's 3UTR in Drosophila spermatogenesis by deleting it and showing that mislocalization, not reduced levels, causes differentiation defects.

The paper shows that PBAP chromatin remodeler subunits BAP170 and SAYP mediate enhancer-driven transcription in Drosophila by recruiting the PBAP complex to promoters.

This study investigates the in vivo functions of BEN-solo proteins in Drosophila embryos, showing they act as insulators to partition active chromatin and regulate gene activation.

The paper shows that boundaries in Drosophila BX-C both block crosstalk between regulatory domains and actively facilitate long-distance communication between domains and their target genes.

The paper identifies a novel role for the iab-7 Polycomb Response Element in boundary function by showing its interaction with the LBC and GAF protein, and reveals that HS1 alone can partially function as a boundary.