Author

Matthew Cook

Yale UniversityORCID 0000-0002-8641-820XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

Christian FreniereiD· 2 shared Faith LozanoiD· 2 shared Yong XiongiD· 2 shared Chunxiang WuiD· 1 shared Pushpanjali Bhardwaj· 1 shared Ryan J. MalonisiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

Christian FreniereORCID

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2 papers

Recent·Most cited

BiochemistryVirusesPeer-reviewedOct 17, 2025

Dissecting the unique self-assembly landscape of the HIV-2 capsid protein

Matthew Cook, Pushpanjali Bhardwaj, Faith Lozano…·Yong Xiong

This study identifies methods for assembling HIV-2 capsid protein lattices and characterizes their biochemical properties, revealing differences in assembly sensitivity and morphology compared to HIV-1.

DOI 10.3390/v17101384

humanproteomics

𝕏 PostBluesky

BiochemistryCell ReportsPeer-reviewedJan 25, 2025

Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single particle cryo-EM.

Matthew Cook, Christian Freniere, Chunxiang Wu…·Yong Xiong

This study determines high-resolution structures of HIV-2 CA lattice using cryo-EM, revealing structural features and differences in host factor interactions compared to HIV-1.

7 citations

viruscryo-EM

𝕏 PostBluesky