Yong Xiong

This study uses DNA-origami rings to investigate FG-Nup interactions and their impact on NPC function, revealing how sequence and post-translational modifications affect protein behavior.

This paper introduces DNA nanorings to dynamically control membrane tension in sub-100 nm liposomes, enabling controlled mechanical stress and molecular cargo release.

This study presents cryo-EM structures of herpesvirus packaging accessory factors, revealing conserved pentameric symmetry and a critical positively charged central channel for genome packaging.

CryoGO provides a method to generate high-resolution structural data of endogenous macromolecules from cells using cryo-EM, enabling detailed structural profiling with minimal sample requirements.

This study reveals the structure and function of the cytoplasmic lattice in mammalian eggs, showing it sequesters ubiquitination machinery and tubulin for use during early embryonic development.

This study reveals how TACO1 enhances mitochondrial translation efficiency by stabilizing tRNA and promoting ribosomal translocation, with implications for bacterial orthologs.

This study identifies a hybrid Gag lattice as an intermediate in HIV-1 maturation, showing it is stabilized by IP6 and essential for infectivity.

The paper uses in situ cryo-EM to visualize human ribosome structures and functional states, revealing new protein interactions and polysome interfaces.

This study determines high-resolution structures of immature HIV-1 particles with inhibitors BVM and LEN bound using cryo-EM, revealing their distinct binding mechanisms and effects on Gag lattice architecture.

This study identifies methods for assembling HIV-2 capsid protein lattices and characterizes their biochemical properties, revealing differences in assembly sensitivity and morphology compared to HIV-1.

This study identifies NOMO as a force-bearing ER transmembrane protein essential for muscle differentiation and ER morphology under mechanical strain.

This study reveals the structural mechanism of human lysyl-tRNA synthetase aminoacylation of modified tRNALys3 using cryo-EM structures.

This study determines high-resolution structures of HIV-2 CA lattice using cryo-EM, revealing structural features and differences in host factor interactions compared to HIV-1.

The paper investigates how varying the width of DNA origami-based nuclear pore mimics affects permeability, showing that narrower pores restrict viral capsid passage while wider pores allow it with NTR assistance.

The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.

The paper introduces a DNA-origami NanoTrap to study diffusion barriers formed by FG-nups and finds that motif type, density, and arrangement are critical for barrier effectiveness.

This study identifies Nsp1 as a key pathogenicity factor of SARS-CoV-2 that redirects host translation machinery to viral RNA by inhibiting cellular protein synthesis and altering gene expression programs.