Chunxiang Wu

This paper introduces DNA nanorings to dynamically control membrane tension in sub-100 nm liposomes, enabling controlled mechanical stress and molecular cargo release.

This study presents cryo-EM structures of herpesvirus packaging accessory factors, revealing conserved pentameric symmetry and a critical positively charged central channel for genome packaging.

CryoGO provides a method to generate high-resolution structural data of endogenous macromolecules from cells using cryo-EM, enabling detailed structural profiling with minimal sample requirements.

This study reveals the structure and function of the cytoplasmic lattice in mammalian eggs, showing it sequesters ubiquitination machinery and tubulin for use during early embryonic development.

This study reveals how TACO1 enhances mitochondrial translation efficiency by stabilizing tRNA and promoting ribosomal translocation, with implications for bacterial orthologs.

This study identifies a hybrid Gag lattice as an intermediate in HIV-1 maturation, showing it is stabilized by IP6 and essential for infectivity.

This study determines high-resolution structures of immature HIV-1 particles with inhibitors BVM and LEN bound using cryo-EM, revealing their distinct binding mechanisms and effects on Gag lattice architecture.

This study determines high-resolution structures of HIV-2 CA lattice using cryo-EM, revealing structural features and differences in host factor interactions compared to HIV-1.

The paper investigates how varying the width of DNA origami-based nuclear pore mimics affects permeability, showing that narrower pores restrict viral capsid passage while wider pores allow it with NTR assistance.