Christian Freniere

This study identifies a hybrid Gag lattice as an intermediate in HIV-1 maturation, showing it is stabilized by IP6 and essential for infectivity.

This study determines high-resolution structures of immature HIV-1 particles with inhibitors BVM and LEN bound using cryo-EM, revealing their distinct binding mechanisms and effects on Gag lattice architecture.

This study identifies methods for assembling HIV-2 capsid protein lattices and characterizes their biochemical properties, revealing differences in assembly sensitivity and morphology compared to HIV-1.

This study determines high-resolution structures of HIV-2 CA lattice using cryo-EM, revealing structural features and differences in host factor interactions compared to HIV-1.