Heidi Kletzien

This study demonstrates CRISPR-HDR efficiency in postnatal cardiac, skeletal muscle, and muscle stem cells, showing developmental stage-dependent HDR rates and successful correction of a Dmd mutation in mdx mice.

The paper creates a mouse model of premalignant oral squamous cell carcinoma and identifies transcriptomic signatures of premalignancy, including immune response enhancement and stem cell dysregulation.

The paper introduces PRINT, a deep learning method to correct chromatin accessibility data and analyze DNA-protein interactions, revealing structural and functional changes in cis-regulatory elements during hematopoiesis and aging.