Ari B. Molofsky

The paper develops a genetically encoded reporter to detect IFN responses in brain and peripheral tissues, revealing coordinated responses in neurons and non-neuronal cells across various conditions.

The paper identifies IAV-driven fibroblast states and shows that loss of TGFβ signaling enhances immuno-modulatory fibroblasts, supporting T2-Tregs to improve lung outcomes.

This study identifies GM-CSF as a key mediator of vertebral bone marrow emergency myelopoiesis in neuropathic pain, linking meningeal immunity to pain pathogenesis.

This study shows that aged fibroblasts activate NF-kB, leading to immune changes like exhausted T cells, autoimmunity, and cancer, increasing susceptibility to age-related diseases.

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

This study compares the skin colonization of Candida auris and C. albicans, finding that C. auris induces IFNγ to enhance its colonization of hair follicles by impairing keratinocyte function.

The paper shows type 1 lymphocytes produce interferon-γ in the thalamus after brain injury, reducing seizure susceptibility by limiting neural hyperexcitability.

This study shows that group 2 innate lymphoid cells (ILC2s) and their cytokine IL-13 promote inhibitory synapse development and adult social behavior.

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

This study identifies IL-33's role in microglial phagocytosis and its impact on synaptic refinement and seizure susceptibility in the developing brain.