Timothy Francis Cloughesy

Synergistic Effects of the DRD2/3 Antagonist ONC201 and Radiation in Glioblastoma

This paper shows that combining ONC201 with radiation improves GBM treatment efficacy by targeting glioma-initiating cells in vitro and in vivo without increased toxicity.

Combined Treatment with Dopamine Receptor Antagonists and Radiation Creates a Metabolic Vulnerability in Mouse Models of Glioblastoma

This study shows that combining quetiapine, atorvastatin, and radiation extends survival in glioblastoma mouse models by exploiting a metabolic vulnerability.

The Dopamine Receptor Antagonist TFP Prevents Phenotype Conversion and Improves Survival in Mouse Models of Glioblastoma