Harley I. Kornblum

Exosome-Mediated Bidirectional Signaling Regulates Glioma Stem-Cell Homeostasis and Radiation-Induced Plasticity

This study shows that exosomes mediate bidirectional signaling between glioma stem cells and non-stem cells, influencing their homeostasis and radiation-induced plasticity.

Temporal Mapping of Radiation-Induced Neural Injury and Mitigation in Human Cortical Organoids

This study uses human cortical organoids to model radiation-induced neural injury and test mitigators, showing partial recovery and transcriptional changes with potential therapeutic interventions.

Critical role of cell competition in gliomagenesis

This study identifies cell competition as a key driver of gliomagenesis by showing that pre-malignant OPCs outcompete wildtype cells, and inhibiting this process reduces tumor growth.

Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma

The paper develops a novel urea-based compound, MXC-017, that crosses the blood-brain barrier, targets glioma stem cells, and improves survival in GBM models when combined with radiation.

Radiation-Induced Cellular Plasticity: A Strategy for Combatting Glioblastoma

This study shows that combining radiation with forskolin induces a differentiation-like state in glioma cells, reducing proliferation and extending survival in mouse models.

Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

This study shows that activation of the mevalonate pathway and Rac-1 in glioblastoma cells after anti-cancer treatments promotes recurrence, and statins combined with radiation improve survival in mouse models.

Single-nucleus analysis characterizes non-enhancing region of recurrent high-grade glioma

The paper uses single-nucleus RNA-sequencing to compare non-enhancing and contrast-enhancing regions of high-grade gliomas, finding distinct cellular states and microenvironment features in NE regions.

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

The paper compares gene expression and stress responses in human and mouse astrocytes, finding conserved and divergent features that may explain differences in disease models.

Synergistic Effects of the DRD2/3 Antagonist ONC201 and Radiation in Glioblastoma

This paper shows that combining ONC201 with radiation improves GBM treatment efficacy by targeting glioma-initiating cells in vitro and in vivo without increased toxicity.

Combined Treatment with Dopamine Receptor Antagonists and Radiation Creates a Metabolic Vulnerability in Mouse Models of Glioblastoma

This study shows that combining quetiapine, atorvastatin, and radiation extends survival in glioblastoma mouse models by exploiting a metabolic vulnerability.

The Dopamine Receptor Antagonist TFP Prevents Phenotype Conversion and Improves Survival in Mouse Models of Glioblastoma

1--4-phenylpiperazine Treatment After Brain Irradiation Preserves Cognitive Function in Mice

This paper shows that Compound #5 reduces radiation-induced cognitive decline in mice without affecting tumor growth.

SCOUT: Single-cell outlier analysis in cancer

SCOUT identifies and analyzes outlier cells in cancer single-cell data to uncover biologically significant information not apparent in whole-population analysis.